1st NeuroMIG Training School
9 – 11 April 2018, Zagreb

University of Zagreb School of Medicine
Croatian Institute for Brain Research

Organised by: COST Action CA: 16118
European Network on Brain Malformations
with University of Zagreb School of Medicine – Croatian Institute for Brain Research

There are still few available slots for grants and registration!

GENOMICS AND IMAGING OF MALFORMATIONS OF BRAIN DEVELOPMENT

1st Neuro-MIG Training School is organized by The European Network on Brain Malformations CA16118

AIM:
The aim of the 1st Neuro-MIG Training School is to convey clinical trends, expertise and knowledge on the care, diagnosis, follow-up, possible treatment options of patients with the MCD and current clinical and basic research on neuronal migration disorders.

TARGET GROUP:
Clinical geneticists, paediatric neurologists, radiologists, laboratory specialists, pathologists, cell biologists and other specialists in the field are welcome. PhD students, postdocs and early career investigators (ECI) with research initiative on neuronal migration disorders and other malformations of cortical development are most welcome.

Number of student participants is limited to 30.

TEACHING STAFF (TRAINERS):
Members of Neuro-MIG COST Action and worldwide known experts will share their expertise with young colleagues through lectures and work on relevant clinical cases in small groups. Concise literature will be distributed to participants in advance.

Call for application is open by March 12th 2018
NO REGISTRATION FEE!

GENOMICS AND IMAGING OF MALFORMATIONS OF BRAIN DEVELOPMENT

The complex issues associated with clinical, radiological and molecular testing strategies of neuronal migration disorders with future perspectives of possible research activities will be challenged. The programme will be focused on the key areas such as:

• Embryogenesis / Neurodevelopment
• Antenatal Diagnosis of brain malformations and its management
• Postnatal diagnosis, treatment, management and follow-up
• Genomics and radiological evaluation
• Future perspectives for brain malformation research
• Model organisms /organoids and future of therapeutic interventions

In the afternoon sessions will be interactive discussions among faculties and students on clinical cases, the harmonisation of daily practice of the care of MCD patients in Europe and neighbouring countries and brainstorming on possible research ideas in the field of MCD.

GENOMICS AND IMAGING OF MALFORMATIONS OF CORTICAL DEVELOPMENT

COST Action European Network on Brain Malformations CA16118
Croatian Institute for Brain Research
School of Medicine of University of Zagreb
9-11th April, 2018

SCIENTIFIC PROGRAM

1st Day – 9th April 2018, Monday

8:15 – 9:00 Registration

9:00 – 9:05 Welcome Address – Dean of SMUZ or Head of the CIBR

9:05– 9:15 European Networks on Brain Malformations COST CA16118

Session 1: Introduction to brain development
Chairpersons: N. Jovanov Milošević and M. Judaš

9:15 – 10:00 Ivica Kostović
The microstructure of the laminar compartments in the cerebral wall: histological-MRI indicators of the typically developing human brain

10:00 – 10:30 Zdravko Petanjek
Dangerous trip for legal immigrants – cortical GABAergic neurons: dispersed origin and expanded time window of production

10:30 – 11:15 Orly Reiner
Developmental and cellular aspects of the brain

11:30-12:00 Coffee Break

Session 2: Session 2: The role of clinical geneticist and the impact of NGS on MCD
Chairpersons: Hulya Kayserili and Andrew Fry

12:00 – 12:30 Grazia Mancini
What is the role of the clinical geneticist in the diagnosis of prenatal MCD

12:30 – 13:00 Peter Bauer
The input of NGS Technology on the diagnosis of Brain Malformation and Identification of Novel Genes
Discussion

13:00 – 14:30 Lunch

Session 3: Case Discussions I.
Chairpersons: Gazia Mancini / Andrew Fry / Maha Zaki / Peter Bauer

14:30 – 15:15 Postnatal cases (solved) Trainers / Trainees

15:15 – 16:00 Postnatal cases (unsolved) Trainers / Trainees

16:00 – 16:30 Coffee Break

Session 4: Team work start-up
Chairpersons: H. Kayserili / Maarten Lequin / Maha Zaki / Nataliya Di Donato

16:30 – 18:00 Team work (in four groups)
Nationwide / Institutional solutions for the definite diagnosis, follow-up strategies and treatment applications, research orientation of MCD group of disorders

20:00 Get Together Dinner (Trainers and Trainees)

2nd Day ; April 10th 2018, Tuesday

Session 5: Child with neurodevelopmental disorders: Challenges to be met
Chairpersons: Grazia Mancini and Zdravko Petanjek

9:30 – 10:00 Andrew Fry
Polymicrogyria – clinical and molecular considerations

10:00 – 10:30 Maha Zaki
Midbrain and hindbrain anomalies

10:30 – 11:00 Nataliya di Donato
Lissencephaly: molecular diagnostics, management and counseling
Discussion

11:00 – 11:30 Coffee Break

Session 6: How to reach to definite diagnosis on MCD
Chairpersons: Andrew Fry/ Hulya Kayserili / Nataliya Di Donato / Maha Zaki

11:30 – 13:00 How to solve the cases?
• Clinical neurologist approach (M. Zaki)
• Clinical dysmorphologist approach (H. Kayserili)
• Medical Geneticist approach ( A. Fry)
• Combined approaches to solve the case ( N. Di Donato)

13:00 – 14:00 Lunch

Session 7: Clinical Radiology
Chairepersons: Maha Zaki and Nataliya Di Donato

14:00 – 14:45 Maarten Lequin
Neuroradiological approach for MCD

14:45 – 15:30 Gustavo Malinger
Early prenatal ultrasonographic findings suggestive of malformations of cortical development
Discussion

15:30 – 16:00 Coffee Break

Case Discussions II. Radiological Assessment of MCD
Chairpersons: Marteen Lequin and Gustavo Malinger

16:00 – 16:45 Antenatal Cases (solved / unsolved)
Trainers / Trainees discussion

16:45 – 17:30 How to read MRIs
Lissencephaly/ tubulinopathies and others
Trainers / Trainees discussion

19:00 Dinner Free night

3rd Day; April 11th 2018, Wednesday

Future of Research and its impact on Neurodevelopmental Disorders
Chairpersons: Grazia Mancini and Andrew Fry

9:00 – 10:00 Renzo Guerrini
Malformations of cortical development and human phenotypes: directions for research

10:00 – 10:30 Nadia Buisson
The phenotypic spectrum of Dyneinopathies: from lissencephaly to Spinal Muscular Atrophy with lower limb predominance

10:30 – 11:00 Miloš Judaš
Cortical changes in holoprosencephaly and Walker –Warburg lissencephaly
Discussion

11:00 – 11:30 Coffee Break

Session 10: Novel tool, organoids
Chairpersons: Renzo Guerrini and Nadia Bahi-Buisson

11:30 – 12:30 Orly Reiner
Brain organoids for studying normal and diseased brain development
Discussion

12:30 – 13:30 Lunch

Session 11 Clinical & molecular genetics and radiology of MCD – Group presentations
Chairpersons: Nadia Bahi-Buisson and Maarten Lequin

13:30-14.15 Quick Quiz (what I have learned on molecular genetics and radiology of neurodevelopmental disorders) Trainers / Trainees
14:15-15.30 Group Presentations (team work)

15:30 – 16:00 Coffee Break

Session 12 Wrap-up and Feedback
Chairpersons: Hulya Kayserili and Nataša Jovanov Milosevic

16:00 –17:00 Wrap-up discussion Trainers / Trainees
Farewell

LIST OF SPEAKERS

Peter Bauer from Centogene, AG, Rostock, Germany
Nadia Buisson, Imagine Institute, INSERM UMR-1163, Paris Descartes University, France
Andrew Fry, Cardiff and Vale UHB – Medical Genetics, UK
Renzo Guerrini, Neuroscience Department, Neurology Unit and Laboratories at Children’s Hospital Anna Meyer, University of Florence, Italy
Ivica Kostović, Croatian Institute for Brain Research, School of Medicine of University of Zagreb, Croatia
Gustavo Malinger, Tel Aviv Sourasky Medical Center | TASMC, OB-GYN Ultrasound Division, Tel Aviv, Israel
Grazia Mancini, Erasmus University Medical Center, Netherlands
Zdravko Petanjek, Department of Anatomy, School of Medicine of University of Zagreb, Croatia
Orly Reiner, Department of Molecular Genetics, Weizmann Institute of Science , Rehovot, Israel
Maha Zaki, National Research Center, Egypt, NRC, Department of Clinical Genetics, Cairo
Hulya Kaserili, Dept. of Medical Genetics, Koç University, School of Medicine,İstanbul, Turkey
Maarten Lequin, Department of Radiology, University Medical Center Utrecht, Netherlands
Miloš Judaš CIBR, School of Medicine of University of Zagreb, Croatia

GENOMICS AND IMAGING OF MALFORMATIONS OF BRAIN DEVELOPMENT

Sixteen scholarships are solicited from Neuro-MIG COST Training School budget. PhD students, postdocs or ECI (less than 8 years after PhD) are eligible for reimbursement, but they will receive reimbursement up to a maximum of 500 Eur. The scholarship is intended to cover registration fee, accommodation and travel costs.

To be eligible for scholarship:

– Abstract (scientific abstract related to MCD topic or to your field of research)
– CV
– Letter of intent
– Support letter from the student home institution is needed.

Five tutors will independently score the students mini portfolios and the decision on scholarship will be announced by the beginning of March. Students will be asked to prepare at least two cases on related topics (antenatal/postnatal cases along with radiological / molecular / histopathological data) to be discussed during the school. Students will also have to prepare 5 ppt slides to present the challenges they encounter in their daily work.

GENOMICS AND IMAGING OF MALFORMATIONS OF BRAIN DEVELOPMENT

The capacity of the venue is maximum 30 students.

All student applications for scholarships will be revised by Training School Committee and the accepted applicants will be informed at latest by the end of February.

To apply for the School and Scholarship, please complete the form online or download
Microsoft Word or
Adobe PDF version
and send it to iva.simunic@btravel.pro

GENOMICS AND IMAGING OF MALFORMATIONS OF BRAIN DEVELOPMENT

TRAINING SCHOOL COMMITTEE CHAIR:
Hülya Kayserili, Koç University, School of Medicine, Istanbul, Turkey

Scientific Organization Committee:
Grazia Mancini, Erasmus University Medical Center, Netherlands
Nadia Buisson, Imagine Institute, INSERM UMR-1163, Paris Descartes University, France
Daniela Pilz, Queen Elizabeth University Hospital, Glasgow, UK

Local Organization Committee:
Nataša Jovanov Milošević, School of Medicine, University of Zagreb, Croatia
Zdravko Petanjek, School of Medicine, University of Zagreb, Croatia
Ivica Kostovic, School of Medicine, University of Zagreb, Croatia

There are plenty of possibilities for accommodations near the School venue:

HIIM – Croatian institute for brain research
University of Zagreb
Address: Šalata 12, HR-10000 Zagreb, Croatia
www.hiim.hr

Rooms available: 13 double rooms for attendees are available for booking.
Contact person for booking at the Dormitory:
Mrs. Branka Duvnjak
Telephone: +385 (0)1 4596-832
E-mail: bvucic@hiim.hr

Important date: Accommodation should be booked until March, 26th 2018.
WORKING HOURS of dormitory paying office (working week): 7.30 – 11.00 h. in office 108 on the first floor

School of Public Health “Andrija Stampar”
University of Zagreb
Address: Rockefellerova 4, HR-10000 Zagreb, Croatia.
www.stampar.hr
Rooms available: 7 double rooms for attendees are available for booking.

Contact person for booking at the Dormitory:
Mrs. Slavica Barbić
Telephone: +385-1-4590-100
E-mail: slavica.barbic@snz.hr
Important date: Accommodation should be booked until March, 26th 2018.

ACCOMODATION TYPE = Double bedroom
PRICE PER NIGHT / PERSON 150 HRK
PRICE IN EURO PER NIGHT/ PERSON 20.50 €

To apply for the accommodation please complete form below:
Microsoft Word version

For more accommodation offers please contact Ms. Iva Simunic: iva.simunic@btravel.pro

BY PLANE | INTERNATIONAL TRANSPORTATION
Arriving by air – Zagreb International Airport

Zagreb International Airport
Address: Ulica Rudolfa Fizira 1
Phone: +385 60 32 03 20
Email: info@mzlz-zagreb-airport.hr
Web: www.zagreb-airport.hr

Zagreb International Airport is only 17 km from the centre, 20-25 minutes by car. To get from the airport to the designated locations there are several transportation option: Taxi, rent-a-car or local bus ride.

From the Airport to the centre or designated locations by

TAXI Zagreb Airport Taxi
+385 98 967 84 24
info@taxi-zagreb.org

Radiotaxi Zagreb +385 1717
Start 10.00 kn (about 1.4 €)
Per km 6,00 kn
One Hour waiting 40.00 kn

Eko taxi +385 1414
START 8,80 kn kn (about 1.2 €)
Per km 6,00 kn
One Hour waiting 43.00 kn

From the Airport to the centre or designated locations by local BUS

Local bus line number 290 can take you to the Kvaternik square from where you can take a bus number 201 to Ruđer Bošković Institute. Both buses are local and stop on every bus stop. Bus line number 290 runs 19km and stops on 20 bus stops. Bus leaves every 35 minute. Download bus 290 route plan HERE.

BY BUS | THE BUS TERMINAL

Zagreb Bus Station is the biggest and most contemporary Station in this area of Europe, which provides its customers with fast and safe transport to any destination in the Republic of Croatia, as well as to bigger European cities.

Information on departures and arrivals: tel. +385 1 60 31 33 33
Information and reservation only from abroad: tel. +385 1 61 12 789
Left-luggage Office (0-24): 5kn/h (for the first 4 hours), every additional hour 2.50kn

BY TRAIN
When traveling by train, the final stop will leave you in the centre of Zagreb. From there, there is an option for a tram that will take you to the the bus station where you can take a bus to the venue of the School – Croatian Institute for Brain Research- CIBR. There are three station to the bus or a 15 minute walk. There is also an option to take only the tram to Andrija Stampar dormitory (Number8).

VENUE: Croatian Institute for Brain Research, University of Zagreb School of Medicine, Šalata 12, 10 000 Zagreb

1st NeuroMIG Training school will be held at the beautiful town of Zagreb, Croatia

ABOUT ZAGREB– CITY WITH A MILLION HEARTS

The city of Zagreb, capital of Croatia, on the historic and political threshold between East and West, illustrates both the continental and Mediterranean spirit of the nation it spearheads. Zagreb is the cultural, scientific, economic, political and administrative centre of the Republic of Croatia, and is home to the Croatian Parliament, Government and President. Its favorable location between the Pannonian plain, the edge of the Alps and the Dinaric range has allowed it to become a crossing point for mass international communication.

The city is protected from the cold northern winds by the mountain of Medvednica and opens up to the rest of the world thanks to a spacious plain and the Sava river. Zagreb, with a population of nearly one million, contains almost a quarter of the entire population of Croatia. Over the centuries, the city was inhabited by people coming from all over Europe; and, in recent years, by people coming from different parts of Croatia, ensuring a rich cultural life. Zagreb is a safe city whose doors are always open; a city with a tumultuous history teeming with interesting personalities; a city that warmly invites all those who wish to get to know it, and a city that will surely fulfill your expectations. In this city, you can easily meet remarkable people, make new friends and enjoy special moments. The façades of Zagreb’s buildings reflect the ebb and flow of history, while its streets and squares bear witness to the coming together of the many cultures that have shaped the identity of this laid-back capital.

Find more >>> http://www.infozagreb.hr/about-zagreb/basic-facts#introduction

DATE: 9 – 11 April 2018, Zagreb, Croatia

LOCAL PUBLIC TRANSPORT

The best means of public transport in Zagreb is the electric tram network regulated by ZET (Zagrebački električki tramvaj). Buses are mostly used through northern, hilly part of Zagreb, and for connecting outskirts with the center of the city.
Download tram map HERE.

CURRENCY AND EXCHANGE RATE

Croatian currency unit is the Croatian Kuna (KN or HRK). Nominal values are:
COINS – 1, 2, 5, 10, 20, 50 lipa; 1, 2, 5, 25 kuna.
NOTES – 5, 10, 20, 50, 100, 200, 500, 1000 kuna.1 kuna = 100 lipas

Domestic currency up to the value of KN 2000 can be exported.
Foreign currencies can be imported and exported freely
For the current exchange rates please check www.hnb.hr

IMPORTANT PHONE NUMBERS

112 Emergency number
192 Police
193 Fire Brigade
194 Ambulance
18981 General Information
11888 Telephone Numbers of Local Subscribers

OPENING HOURS

Banks
07.30-20.00 Monday to Friday, 08.00-12.00 Saturday

Shops
08.00-20.00 Monday to Friday, 08.00-14.00 Saturday

Shopping centers
10.00 – 22.00 Monday to Sunday

Training School Committee:
Hulya Kayserili
hkayserili@kuh.ku.edu.tr

Local Organization Committee:
Nataša Jovanov Milošević
njovanov@hiim.hr
njovanov@mef.hr

Registaration, accommodation and general information:
Željka Pavlović
zorsag@hiim.hr
Iva Šimunić
iva.simunic@btravel.pro